Unveiling the Mystery of Tadalafila

The question you want to ask may be "tadalafil".

1. Basic information

1、medication type

- Tadalafil is a drug used to treat erectile dysfunction (ED) and is a phosphodiesterase type 5 (PDE5) inhibitor.

2、mechanism of action

- During sexual stimulation, neurons and endothelial cells in the corpus cavernosum of the penis release nitric oxide (NO). NO activates guanylate cyclase and increases cyclic guanosine phosphate (cGMP) levels, which leads to relaxation of smooth muscles. Blood flows into the corpus cavernosum of the penis, causing erection.

- While PDE5 can decompose cGMP, tadalafil inhibits PDE5 and increases the concentration of cGMP, thereby enhancing erectile function.

2. Clinical application

1、Treatment of erectile dysfunction

- Tadalafil can be taken on demand, and there are also regular schedules. When taken on demand, it is usually taken some time before sexual activity; regular taking can improve patients 'erectile function and increase satisfaction in sexual life.

2、Treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH)

- Tadalafil can relax the smooth muscle of the prostate and bladder neck and improve lower urinary tract symptoms, such as frequent frequency, urgency, and inexhaustible urine. For patients with both ED and BPH, using tadalafil has certain advantages.

3. Matters needing attention

1、contraindications

- Tadalafil is contraindicated for patients who are taking any form of nitrates, such as nitroglycerin, because combination of the two may cause severe hypotension.

- It is contraindicated for people allergic to tadalafil.

2、adverse reactions

- Common adverse reactions include headache, indigestion, back pain, myalgia, flushing, etc. These adverse reactions are mostly mild and transient. In clinical use, doctors will weigh the pros and cons according to the patient's specific conditions before using them.