What is Tadalafil used for?

Tadalafil is primarily used for the following purposes:

1. Treatment of erectile dysfunction (ED)

Mechanism for action:

-Tadalafil inhibits the type 5 phosphodiesterase enzyme (PDE-5), which is responsible for degrading nitrogen monoxide (no)-dependent on cyclic monophosphate guanosin (cGMP) in penile cavernous tissue. By inhibiting PDE-5, the concentration of cGMP is increased, resulting in relaxation of smooth muscles in the penis and allowing increased blood flow to cavernous tissue, facilitating erection.

Effectiveness:

-help men with SD achieve and maintain sufficient erections for satisfactory sexual activity.

2. Treatment of pulmonary hypertension (HP)

Mechanism of action in HP:

-in pulmonary hypertension, tadalafil works by relaxing the smooth muscles of the pulmonary blood vessels. This decreases pulmonary vascular resistance, facilitating blood flow through the lungs and improving cardiopulmonary function.

Benefits in HP:

-it can improve exercise capacity, quality of life and respiratory symptoms associated with pulmonary hypertension.

It is important to note that tadalafil should be prescribed by a doctor and consideration should be given to possible side effects and contraindications. Some common side effects include headache, pain in the abdomen, nasal congestion, and dizziness.