All about Tadalafilo 5 mg: What You Need to Know
Gui í a de Salud Masculina
Tadalafil (tadalafil) 5 mg is a drug dose specification for the treatment of erectile dysfunction (ED) and pulmonary hypertension (PAH). Here are some details about it:
I. Pharmacological action
1 、In the treatment of erectile dysfunction
Tadalafil is a selective phosphodiesterase 5 (PDE5) inhibitor. During sexual stimulation, nerve endings and endothelial cells in the penile sponge release nitric oxide (NO). NO activates guanosine cyclase to increase the production of cyclic guanosine monophosphate (cGMP). CGMP relaxes the smooth muscle of the corpus cavernosum and causes blood to flow into the cavernous body of the penis, which promotes an erection of the penis.
PDE5 degrades cGMP, while tadalafil inhibits PDE5, thereby increasing the concentration of cGMP and maintaining penile erectile function.
2 、Treatment of pulmonary hypertension
-in pulmonary vascular smooth muscle cells, the increase of PDE5 activity is related to the pathophysiological process of pulmonary hypertension. Tadalafil relaxes pulmonary vascular smooth muscle, reduces pulmonary artery pressure and improves right ventricular function by inhibiting PDE5 and increasing the content of cGMP in pulmonary vascular smooth muscle cells.
II. Usage
1 、Treatment of erectile dysfunction
-for most patients, the initial dose is 10mg before having sex, but 5mg can be used in a daily low-dose regimen, which can maintain a stable blood concentration after continuous administration for a period of time, and may have a better effect on improving erectile function. And may reduce the effect of drugs taken on demand affected by factors such as food and alcohol consumption.
It is generally not affected by eating and can be taken before or after meals.
2 、Treatment of pulmonary hypertension
-it usually starts with a dose of 40mg (once a day), but in some cases it is possible to start treatment with a low dose of 5mg once a day, and then gradually adjust the dose according to the patient's tolerance and treatment response.
Matters needing attention
1 、Adverse reaction
Common adverse reactions include headache, indigestion, back pain, myalgia, nasal congestion, etc. Most of these adverse reactions are mild to moderate and usually temporary.
-in rare cases, serious adverse reactions may occur, such as persistent erection (priapism, penile erection for more than 4 hours), which, if left untreated, may cause damage to the corpus cavernosum tissue.
2 、Contraindication
-patients who are using any form of organic nitrates, such as nitroglycerin, disable tadalafil because a combination of the two can lead to severe hypotension.
-it is forbidden for people who are allergic to tadarafi.
3 、Interaction with other drugs
Tadalafil is metabolized mainly by cytochrome P450 (CYP) 3A4. Some strong CYP3A4 inhibitors (such as ketoconazole, itraconazole, etc.) will slow down tadalafil metabolism, which may increase the blood concentration of tadalafil and increase the risk of adverse reactions.
-when used with alpha-blockers (such as tamsulosin, etc.), it may increase the risk of hypotension. Care should be taken at the beginning of use and blood pressure should be closely monitored.
Before using tadalafil 5mg or any tadalafil preparation, it should be carried out under the guidance of a doctor to ensure safe and effective use.